Bio-Synthesis Inc. Introduces “BNA-NC”

The third generation of 2′,4′-BNA-NC contains a 6-membered ring with a N-O bond between the 2′-hydroxyl and the 4′-carbon of the ribose moiety. It exhibits very strong binding affinity to complementary single stranded RNA, DNA, and double stranded DNA with a highly sequence-selective mode. In particular, the binding ability to complementary RNA is significantly high. BNA-NC also possesses great stability due to its nuclease resistant properties. (Follow the full Press Release here.)

BNA Features Improved hybridization selectivity and specificity Increased thermal duplex stability Enhanced allelic discrimination High biological stability to nuclease and protease Superior antisense inhibition and potency Flexible probe designs regardless of GC content Easily adaptable to many DNA or RNA detection system

Applications Antigene inhibition Inhibition of RNA function Real-time/ qPCR SNP detection /allele specific PCR In situ hybridization DNAzymes and Ribozymes Biosensor and more

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