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Article of Interest (Coagulation) -The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors.
What is already known about this subject: A number of pharmacokinetics studies have focused on S-warfarin. These have shown that demographic factors, such as bodyweight, genetic factors, such as CYP2C9 genotype, and interacting medicines, particularly amiodarone, contribute to the interindividual estimates of clearance. What this study adds: This study not only reinforces what has previously been learned about S-warfarin, but also provides an insight into the pharmacokinetics of R-warfarin.
Largest Selection of β-Amyloid and Related Peptides from Bio-Synthesis Inc.
Amyloid Precursor Protein (APP) is a transmembrane protein that is predominantly expressed in the brain. Mutations and subsequent cleavages of APP by β-secretase, ϒ-secretase and caspases generated amyloid beta peptides, which have been implicated in the pathogenesis of Alzheimer's disease. Proteolytic action of β-secretase and ϒ-secretase generates amyloid β peptides of 40 or 42 residues. These peptides are susceptible to aggregate and lead to formation of amyloid plaques that characterizes Alzheimer disease.
Selected Publications Citing 21st Century Biochemicals Custom Antibodies
Quadratech supplies high quality Epigenetic Peptides and Antibodies, Custom Peptides, Custom Antibodies, Antibodies to Selected Targets and Bioactive Peptides. These have been successfully used in many research laboratories.
New Products from Bio-Synthesis: GLYCOPEPTIDES
Biomedical Applications of Glycopeptides Diagnostics–Glycated peptides can serve as biomarkers to monitor the onset of diseases such as hyperglycemia, diabetes and its complications. Studies have shown that in diabetic patients,proteins including Hemoglobin A, Human Serum Albumin(HSA),Fibrinogen are extensively glycated. Diseases Therapy–age–related neurodegenerative diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis have been associated with increased AGE’s formation.Glycopeptides can therefore serve as biological markers to evaluate the efficacy of disease therapy.
Intergrated Solutions: Cell Penetrating Peptides
Bio-Synthesis is a leading global manufacturer of high quality custom peptides and oligonucleotides. Their expertise includes the ability to design and manufacture advanced peptide-bioplymer bioconjugation for biopharmaceutical, diagnostic, and research applications.
Quadratech 2012 Newsletter Back Issues
Back issues of Quadratech 2012 newsletters are available for viewing and downloading.
Bio-Synthesis Inc. Introduces “BNA-NC”
Bio-Synthesis Inc. Introduces "BNA-NC" - A Third Generation Multi Functional Bridged Nucleic Acid Bio-Synthesis is proud to announce that it has acquired a license from BNA Inc. of Osaka, Japan for the manufacturing and distribution of BNA-NC, a third generation of BNA oligonucleotides. This agreement is valid worldwide and is meant for research use only at this time (Patents JP: 4731324(2011.4.28), USP: 7427672(2008.9.23), EP: 1551905(2012.4.25)).
New Assays For Measuring Direct Thrombin Inhibitors in Plasma
Direct Thrombin Inhibitors (DTIs) have increasing and promising curative, preventive or prophylactic applications in severe clinical situations. Laboratory methods are required for adjustment of drug efficacy and for avoiding overdosage. Specialized calibrated clotting and chromogenic assays for quantitating various DTIs have been developed and compared for their efficacy. Results show excellent performance with Hirudin and analogues, but were not found to be suitable for the Argatroban® usual therapeutic range.
55th Annual Meeting Society of Thrombosis and Haemostasis Research – [Anti-FVIII]
Development of an individual Anti-FVIII Inhibitors ELISA to improve Haemophiliacs therapeutic follow up Peyrafitte M.1, Vissac A.M.1, Amiral J.2 1HYPHEN BioMed, Research, Neuville sur Oise, France. 2HYPHEN BioMed, Neuville sur Oise, France
55th Annual Meeting Society of Thrombosis and Haemostasis Research – [PS]
Highly stable and robust protein S clotting assay validated for easier laboratory practice Amiral J.1, Peyrafitte M.2, Vissac A.M.2 1HYPHEN BioMed, Neuville sur Oise, France. 2HYPHEN BioMed, Research, Neuville sur Oise, France
55th Annual Meeting Society of Thrombosis and Haemostasis Research – [Dabigatran]
Dabigatran calibrator and control plasmas for drug measurement in plasma, when required Amiral J.1, Stangier J.2, Peyrafitte M.1 1HYPHEN BioMed, research, Neuville sur Oise, France. 2Boehringer Ingelheim Pharma Gmbh & Co KG, Biberach an der Riss, Germany
55th Annual Meeting Society of Thrombosis and Haemostasis Research – [TF]
Microparticles exposing Tissue Factor in human plasma Laroche M.1, Vissac A.M.1, Peyrafitte M.1, Amiral J.2 1HYPHEN BioMed, Research, Neuville sur Oise, France 2HYPHEN BioMed, Neuville sur Oise, France
