Lysis Timer
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Lysis Timer (LT-8V) is a handheld device to evaluate the body’s global fibrinolytic capacity (GFC) in citrated plasma. Manufactured by HYPHEN BioMed.
This instrument is for research use only and must not be used for patient diagnosis or treatment.
The Lysis Timer (LT) is a handheld device, recently optimized by HYPHEN BioMed to evaluate the body’s global fibrinolytic capacity (GFC) in citrated plasma. The GFC/LT method has the advantage to provide results in less than 1 hour and provides better performances than viscoelastic tests.
Fibrinolysis is the mechanism leading to fibrin clot dissolution in order to restore vessel patency or to dissolve a clot following the healing of a vessel injury. It involves various proteins, that act either as inhibitors, delaying clot dissolution, (PAI-1, Alpha-2-antiplasmin, TAFI, HRGP…), or as activators that enable fibrin polymer breakdown (tPA, uPA, plasminogen). Plasminogen plays the central role in that process: after its activation into plasmin by either tissue plasminogen activator (tPA) or urokinase (uPA), it cleaves fibrin polymer.
Hyperfibrinolysis has been associated with mild to severe bleeding tendency, especially during surgery and invasive procedures. It is associated with increased morbidity and mortality.
Hypofibrinolysis is a risk factor for thrombosis and may become a predictive marker of venous thromboembolism and arterial thrombosis.
The many implications of fibrinolysis in human physiology demonstrate how critical this system is for the integrity of life and for the right balance of many biological functions. Until now, it has always been time-consuming, difficult and incomplete to explore fibrinolysis. Today, the Lysis Timer (LT) instrument, paired with the GFC reagents, can fill this gap by providing fast and reliable results.
