Norovirus GII.4 VLP (1000µg) (Special Terms Apply*)
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Norovirus GII.4 VLP (1000µg) (Special Terms Apply*) (QTXAG-480-1000) is recombinant Norovirus GII.4 VP1 Virus-Like Particles produced in mammalian HEK293 cells. Norovirus VP1 structural protein is transiently expressed to form a particle without the non-structural proteins or genome. Resultant particles are totally non-infectious. Purity greater than 95%.
Norovirus VP1 protein is the capsid protein of Norovirus. It is a 59kD glycoprotein with three key domains. The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into sub-domains P1 and P2. P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. An hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.
The Norovirus VP1 protein self-assembles to form the Norovirus virion, containing 180 copies of the protein. produce VP1 protein in a mammalian cell expression system, which produces intact virus-like particles (VLPs) of very high purity. These VLPs are suitable for studies of VP1 structure, and also as potential targets for serological assays.
*Special Terms: Please see product specification details below and our Ordering page for details.
Q-TOX Term 2: Minimum Order Volume of 1000µg on Orders Requiring Dry Ice Shipment
